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dilisym pbpk submodel  (DILIsym Services Inc)

 
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    DILIsym Services Inc dilisym pbpk submodel
    Parameters Used in the <t> DILIsym PBPK Submodel </t> for Riluzole
    Dilisym Pbpk Submodel, supplied by DILIsym Services Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pbpk+submodels/pmc07253195-58-4-4?v=DILIsym+Services+Inc
    Average 90 stars, based on 1 article reviews
    dilisym pbpk submodel - by Bioz Stars, 2026-07
    90/100 stars

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    1) Product Images from "Assessing Effects of BHV-0223 40 mg Zydis Sublingual Formulation and Riluzole 50 mg Oral Tablet on Liver Function Test Parameters Utilizing DILIsym"

    Article Title: Assessing Effects of BHV-0223 40 mg Zydis Sublingual Formulation and Riluzole 50 mg Oral Tablet on Liver Function Test Parameters Utilizing DILIsym

    Journal: Toxicological Sciences

    doi: 10.1093/toxsci/kfaa019

    Parameters Used in the DILIsym PBPK Submodel for Riluzole
    Figure Legend Snippet: Parameters Used in the DILIsym PBPK Submodel for Riluzole

    Techniques Used: Clinical Proteomics, Protein Binding, Molecular Weight



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    Diagrams of hepatobiliary disposition of bilirubin ( a ) and the bilirubin <t>submodel</t> structure within DILIsym ( b ). CB, conjugated bilirubin; DJS, Dubin‐Johnson Syndrome; GS, Gilbert's Syndrome; HC, hepatocytes; MRP, multidrug resistance‐associated protein; OATP, organic anion transporting polypeptide; RBC, red blood cell; RS, Rotor Syndrome; UB, unconjugated bilirubin; UGT, UDP glucuronosyltransferase.
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    List of parameters varied in the SimPops™ and results of multiple‐regression analysis in SimPops™ administered tolcapone (200 mg t.i.d. for 1 week)
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    physiologically-based pharmacokinetic (pbpk) submodel  (DILIsym Services Inc)
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    Parameters Used in the DILIsym PBPK Submodel for Riluzole

    Journal: Toxicological Sciences

    Article Title: Assessing Effects of BHV-0223 40 mg Zydis Sublingual Formulation and Riluzole 50 mg Oral Tablet on Liver Function Test Parameters Utilizing DILIsym

    doi: 10.1093/toxsci/kfaa019

    Figure Lengend Snippet: Parameters Used in the DILIsym PBPK Submodel for Riluzole

    Article Snippet: The structure of the DILIsym PBPK submodel has been discussed in detail elsewhere ( Howell et al. , 2012 ; Woodhead et al. , 2012 , ).

    Techniques: Clinical Proteomics, Protein Binding, Molecular Weight

    Diagrams of hepatobiliary disposition of bilirubin ( a ) and the bilirubin submodel structure within DILIsym ( b ). CB, conjugated bilirubin; DJS, Dubin‐Johnson Syndrome; GS, Gilbert's Syndrome; HC, hepatocytes; MRP, multidrug resistance‐associated protein; OATP, organic anion transporting polypeptide; RBC, red blood cell; RS, Rotor Syndrome; UB, unconjugated bilirubin; UGT, UDP glucuronosyltransferase.

    Journal: Clinical Pharmacology and Therapeutics

    Article Title: Systems pharmacology modeling of drug‐induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters

    doi: 10.1002/cpt.619

    Figure Lengend Snippet: Diagrams of hepatobiliary disposition of bilirubin ( a ) and the bilirubin submodel structure within DILIsym ( b ). CB, conjugated bilirubin; DJS, Dubin‐Johnson Syndrome; GS, Gilbert's Syndrome; HC, hepatocytes; MRP, multidrug resistance‐associated protein; OATP, organic anion transporting polypeptide; RBC, red blood cell; RS, Rotor Syndrome; UB, unconjugated bilirubin; UGT, UDP glucuronosyltransferase.

    Article Snippet: Physiological parameters for tissue volumes and blood flows in the PBPK submodel of DILIsym were published elsewhere.

    Techniques:

    List of parameters varied in the SimPops™ and results of multiple‐regression analysis in SimPops™ administered tolcapone (200 mg t.i.d. for 1 week)

    Journal: CPT: Pharmacometrics & Systems Pharmacology

    Article Title: Elucidating Differences in the Hepatotoxic Potential of Tolcapone and Entacapone With DILIsym ® , a Mechanistic Model of Drug‐Induced Liver Injury

    doi: 10.1002/psp4.12053

    Figure Lengend Snippet: List of parameters varied in the SimPops™ and results of multiple‐regression analysis in SimPops™ administered tolcapone (200 mg t.i.d. for 1 week)

    Article Snippet: Via the use of PBPK submodels developed to describe the disposition of tolcapone and entacapone, DILIsym ® predicted lower hepatic exposure for entacapone than for tolcapone for clinically relevant dosing regimens of each compound.

    Techniques: